Search Results for: Zinc

November 9, 2019November 9, 2019

Zinc Fingers

Publication date: Nov 09, 2019 Ed is a consultant neurologist at the National Hospital for Neurology and Neurosurgery and Associate Director of the UCL Huntington’s Disease Centre, where his research ... Read more

September 22, 2019September 22, 2019

The Zinc-finger AN1-type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2.

Melanoma Literature

Publication date: Sep 20, 2019 The zinc-finger AN1-type domain-2a gene, also known as AIRAP, was initially described as an arsenite-inducible gene in C. elegans and mammalian cells. Differently from the ... Read more

September 15, 2019September 15, 2019

Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington’s Disease.

Huntington's Disease Literature

Publication date: Sep 13, 2019 There is currently no disease-modifying treatment for Huntington’s disease (HD), which is characterized by chorea motor impairment and cognitive decline. The zinc ionophore, PBT2, was ... Read more

July 3, 2019July 3, 2019

The activity of disease allele-selective zinc finger proteins in preclinical models of Huntington’s disease

Huntington's Disease News

Publication date: Jul 03, 2019 Credit: CC0 Public Domain Sangamo Therapeutics, Inc. , a genomic medicine company, today announced the publication of a manuscript describing the activity of allele-selective zinc ... Read more

May 3, 2019May 3, 2019

Translating nanomedicine to comparative oncology: the case for combining zinc oxide nanomaterials with nucleic acid therapeutic and protein delivery for treating metastatic cancer.

Melanoma Literature

Publication date: Apr 30, 2019 The unique anticancer, biochemical and immunological properties of nanomaterials are becoming a new tool in biomedical research. Their translation into the clinic promises a new ... Read more

April 24, 2019April 24, 2019

Zinc-Finger Repressive Proteins Show Promise as Treatment for Huntington’s in Mouse Studies

Huntington's Disease News

Publication date: Apr 23, 2019 This post was originally published on this site A protein that can specifically bind to mutated forms of huntingtin and prevent its production – while ... Read more

February 1, 2019February 1, 2019

miR-30a Inhibits Melanoma Tumor Metastasis by Targeting the E-cadherin and Zinc Finger E-box Binding Homeobox 2.

Melanoma Literature

Publication date: Jan 01, 2019 Epithelial-mesenchymal transition (EMT) is actively involved in tumor invasion. The main hallmark of EMT is downregulation of the adherens junction protein E-cadherin due to transcriptional ... Read more

January 4, 2019January 4, 2019

Oxidative stress generated by irradiation of a zinc(II) phthalocyanine induces a dual apoptotic and necrotic response in melanoma cells.

Melanoma Literature

Publication date: Jan 02, 2019 Melanoma is an aggressive form of skin carcinoma, highly resistant to traditional therapies. Photodynamic therapy (PDT) is a non-invasive therapeutic procedure that can exert a ... Read more

January 1, 2019January 1, 2019

A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell’s photodynamic therapy (PDT).

Melanoma Literature

Publication date: Jan 01, 2019 Zn-based phthalocyanine acts as drug or photosensitizer in photodynamic therapy (PDT) for the treatment of cancer cells. The activated zinc octacarboxyphthalocyanine (ZnPcOC) reacts with oxygen, ... Read more

July 28, 2018July 28, 2018

Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls.

Multiple Sclerosis Literature

Publication date: Jul 26, 2018 Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to ... Read more