Search Results for: antibody

March 24, 2025March 24, 2025

Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants.

Publication date: Mar 22, 2025 Medical treatments using potent neutralizing SARS-CoV-2 antibodies have achieved remarkable improvements in clinical symptoms, changing the situation for the severity of COVID-19 patients. We previously ... Read more

March 22, 2025March 22, 2025

Redirecting the host immune response to bacterial infection with antibody-recruiting molecules (ARMs).

Tuberculosis Literature

Publication date: Mar 20, 2025 The increasing prevalence of antibiotic resistance, the stagnation of antibiotic development, and the adaptive capacity of bacteria to subvert the host immune response combine to ... Read more

March 22, 2025March 22, 2025

Regulated somatic hypermutation enhances antibody affinity maturation.

Coronavirus Literature

Publication date: Mar 19, 2025 Germinal centres are specialized microenvironments where B cells undergo affinity maturation. B cells expressing antibodies whose affinity is improved by somatic hypermutation are selected for expansion by ... Read more

March 22, 2025March 22, 2025

Regulated somatic hypermutation enhances antibody affinity maturation.

Coronavirus Literature

March 22, 2025March 22, 2025

Effect of pre-vaccination blood and T-cell phenotypes on antibody responses to COVID-19 mRNA vaccine.

Coronavirus Literature

Publication date: Mar 20, 2025 Despite the high effectiveness of the coronavirus disease (COVID-19) mRNA vaccines, both immunogenicity and reactogenicity show substantial interindividual variability. One key challenge is predicting high ... Read more

March 22, 2025March 22, 2025

Effect of pre-vaccination blood and T-cell phenotypes on antibody responses to COVID-19 mRNA vaccine.

Coronavirus Literature

March 21, 2025March 21, 2025

Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design.

Coronavirus Literature

Publication date: Jun 02, 2025 Autoantibodies neutralizing type I interferons (IFN-Is; IFNα or IFNω) exacerbate severe viral disease, but specific treatments are unavailable. With footprint profiling, we delineate two dominant ... Read more

March 20, 2025March 20, 2025

Time course and determinants of the antibody response to SARS-CoV-2 in Costa Rica: the RESPIRA study.

Coronavirus Literature

Publication date: Mar 18, 2025 Antibodies to SARS-CoV-2 are essential for protection or reduction in severity of subsequent disease. We studied antibody responses to spike protein receptor-binding domain (S1-RBD) and ... Read more

March 20, 2025March 20, 2025

Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals.

Coronavirus Literature

Publication date: Mar 18, 2025 With the continued emergence of SARS-CoV-2 variants and concerns of waning immunity, there is a need for better defined correlates of protection to aid future ... Read more

March 20, 2025March 20, 2025

Exploring exhaled volatile organic compounds as potential biomarkers in anti-MDA5 antibody-positive interstitial lung disease.

Melanoma Literature

Publication date: Mar 18, 2025 Interstitial lung diseases (ILDs) are a group of pulmonary disorders characterized by fibrosis, inflammation, and lung tissue deterioration. Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung ... Read more