Search Results for: defects

June 15, 2019June 15, 2019

Sleep Deprivation caused a Memory Defects and Emotional Changes in a Rotenone-based Zebrafish Model of Parkinson’s Disease.

Publication date: Jun 10, 2019 Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the world. Apart from motor deficits, PD reduces patient’s quality of life through sleep ... Read more

June 4, 2019June 4, 2019

Nucleocytoplasmic transport defects in neurodegeneration – cause or consequence?

Huntington's Disease Literature

Publication date: May 29, 2019 Defects in nucleocytoplasmic transport have been associated with several neurodegenerative disorders and, in particular, the formation of pathological protein aggregates characteristic for the respective disease. ... Read more

April 25, 2019April 25, 2019

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease.

Huntington's Disease Literature

Publication date: Apr 23, 2019 White matter abnormalities are a nearly universal pathological feature of neurodegenerative disorders including Huntington disease (HD). A long-held assumption is that this white matter pathology ... Read more

April 11, 2019

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.

Melanoma Literature

Publication date: Apr 01, 2019 Although the majority of BRAF-mutant melanomas respond to BRAF/MEK inhibitors, these agents are not typically curative. Moreover, they are largely ineffective in NRAS- and NF1-mutant ... Read more

April 1, 2019April 1, 2019

Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer.

Precision Medicine News

Publication date: Apr 01, 2019 In this manuscript, we review the current knowledge on DNA repair defects in prostate cancer and provide an overview of how these alterations can be ... Read more

March 29, 2019March 29, 2019

Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer.

Precision Medicine Literature

Publication date: Mar 27, 2019 Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ... Read more

March 28, 2019March 28, 2019

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Huntington's Disease Literature

Publication date: Mar 26, 2019 Mitochondrial fragmentation and bioenergetic failure manifest in Huntington’s disease (HD), a fatal neurodegenerative disease. The factors that couple mitochondrial fusion/fission with bioenergetics and their impacts ... Read more

February 8, 2019February 8, 2019

Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.

Huntington's Disease Literature

Publication date: Feb 06, 2019 High levels of oxidative stress is detected in neurons affected by many neurodegenerative diseases, including huntington’s disease. Many of these diseases also show neuronal cell ... Read more

February 8, 2019February 8, 2019

Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.

Huntington's Disease Literature

December 21, 2018December 21, 2018

Human ESC-Derived Chimeric Mouse Models of Huntington’s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.

Huntington's Disease Literature

Publication date: Nov 23, 2018 Huntington’s disease (HD) is characterized by hypomyelination and neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells ... Read more