Search Results for: defects

October 10, 2019October 10, 2019

Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology.

Publication date: Oct 08, 2019 Artificial intelligence (AI) is one of the key drivers of digital health. Digital health and AI applications in medicine and biology are emerging worldwide, not ... Read more

August 21, 2019August 21, 2019

Calcium-Handling Defects and Neurodegenerative Disease.

Huntington's Disease Literature

Publication date: Aug 19, 2019 Calcium signaling is critical to neuronal function and regulates highly diverse processes such as gene transcription, energy production, protein handling, and synaptic structure and function. ... Read more

August 21, 2019August 21, 2019

Calcium-Handling Defects and Neurodegenerative Disease.

Huntington's Disease Literature

June 30, 2019June 30, 2019

Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Precision Medicine Literature

Publication date: Jun 28, 2019 Neoantigens that arise as a consequence of tumor-specific mutations can be recognized by T lymphocytes leading to effective immune surveillance. In colorectal cancer (CRC) and ... Read more

June 4, 2019June 4, 2019

Nucleocytoplasmic transport defects in neurodegeneration – cause or consequence?

Huntington's Disease Literature

Publication date: May 29, 2019 Defects in nucleocytoplasmic transport have been associated with several neurodegenerative disorders and, in particular, the formation of pathological protein aggregates characteristic for the respective disease. ... Read more

April 25, 2019April 25, 2019

Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease.

Huntington's Disease Literature

Publication date: Apr 23, 2019 White matter abnormalities are a nearly universal pathological feature of neurodegenerative disorders including Huntington disease (HD). A long-held assumption is that this white matter pathology ... Read more

April 11, 2019

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.

Melanoma Literature

Publication date: Apr 01, 2019 Although the majority of BRAF-mutant melanomas respond to BRAF/MEK inhibitors, these agents are not typically curative. Moreover, they are largely ineffective in NRAS- and NF1-mutant ... Read more

April 1, 2019April 1, 2019

Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer.

Precision Medicine News

Publication date: Apr 01, 2019 In this manuscript, we review the current knowledge on DNA repair defects in prostate cancer and provide an overview of how these alterations can be ... Read more

March 29, 2019March 29, 2019

Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer.

Precision Medicine Literature

Publication date: Mar 27, 2019 Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ... Read more

March 28, 2019March 28, 2019

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Huntington's Disease Literature

Publication date: Mar 26, 2019 Mitochondrial fragmentation and bioenergetic failure manifest in Huntington’s disease (HD), a fatal neurodegenerative disease. The factors that couple mitochondrial fusion/fission with bioenergetics and their impacts ... Read more