Publication date: May 15, 2022 Vascular endothelial growth factor (VEGF) is an important over-expressed growth protein during cell proliferation process, which has been regarded as a pivotal biomarker of several ... Read more

Publication date: May 01, 2022 Previous studies suggest that polygenic risk scores (PRSs) may improve melanoma risk stratification. However, there has been limited independent validation of PRS-based risk prediction, particularly ... Read more

Publication date: Mar 01, 2022 Tumor microenvironment plays an important role in melanoma progression. Recent studies reported endothelial cells (EC) are involved in endothelial-to-mesenchymal transition (EndMT). During this phenotypic switch, ... Read more

Publication date: May 01, 2022 ICER is a transcriptional repressor that is mono- or poly-ubiquitinated. This either causes ICER to be translocated from the nucleus, or degraded via the proteasome, ... Read more

Publication date: Apr 30, 2022 Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the ... Read more

Publication date: Apr 29, 2022 Chlorin e6-C-15-ethyl ester (LS-HB), a newly identified photosensitizer, was isolated from chlorin e6. The mechanism of tumor cell death induced by photodynamic therapy with LS-HB ... Read more

Publication date: Apr 20, 2022 Accumulation of senescent cells in various tissues has been reported to have a pathological role in age-associated diseases. Elimination of senescent cells (senolysis) was recently ... Read more

Publication date: Apr 07, 2022 Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. ... Read more

Publication date: Apr 05, 2022 Although an increasing number of patients benefit from immunotherapy and targeted therapies, melanoma remains incurable with increasing incidence. Drug repositioning and repurposing is an alternative ... Read more

Publication date: Mar 28, 2022 In spite of the good prognosis of patients with early-stage melanoma, there is a substantial proportion of them that develop local or distant relapses. With ... Read more