Search Results for: gene

December 9, 2024December 9, 2024

Health service access and quality of care provided by the Western NSW Local Health District Virtual Rural Generalist Service: a retrospective analysis of linked administrative data.

Publication date: Dec 09, 2024 To evaluate the quantity and quality of medical care provided by the Western NSW Local Health District Virtual Rural Generalist Service (VRGS). Retrospective cohort study; ... Read more

December 9, 2024December 9, 2024

An economic evaluation of the Virtual Rural Generalist Service versus usual care in Western NSW Local Health District.

Coronavirus Literature

Publication date: Dec 09, 2024 Evaluate the cost-effectiveness of the Virtual Rural Generalist Service (VRGS) model of care. A cost-consequence analysis of the VRGS model of care compared with usual ... Read more

December 9, 2024December 9, 2024

Generalized Association Rules for Connecting Biological Ontologies

Dr. Richard A. Blevins News, Informatics News

Publication date: Dec 07, 2024 GPCR databases. In this way found association rules connecting two biological ontologies can provide the user with new knowledge about underlying biological processes. The preliminary ... Read more

December 8, 2024December 8, 2024

Modelling the stochastic importation dynamics and establishment of novel pathogenic strains using a general branching processes framework.

Coronavirus Literature

Publication date: Dec 05, 2024 The importation and subsequent establishment of novel pathogenic strains in a population is subject to a large degree of uncertainty due to the stochastic nature ... Read more

December 8, 2024December 8, 2024

CRISPR-Cas9 screening identified novel subtypes of cutaneous melanoma based on essential cancer genes.

Melanoma Literature

Publication date: Dec 07, 2024 Our primary objective was to identify genes critical for cutaneous melanoma (CM) and related typing, based on essential genes, to generate novel insights for clinical ... Read more

December 8, 2024December 8, 2024

Protocol for chemogenetic activation of basal ganglia D1-MSNs and behavioral assessments in a primate Parkinson’s disease model.

Parkinson's Disease Literature

Publication date: Dec 05, 2024 A circuit-based gene therapy strategy for Parkinson’s disease (PD) has been shown to significantly reverse core symptoms in both murine and primate PD models. Here, ... Read more

December 8, 2024December 8, 2024

Glutathione S-transferase: A keystone in Parkinson’s disease pathogenesis and therapy.

Parkinson's Disease Literature

Publication date: Dec 05, 2024 Parkinson’s disease is a progressive neurodegenerative disorder that predominantly affects motor function due to the loss of dopaminergic neurons in the substantia nigra. It presents ... Read more

December 8, 2024December 8, 2024

Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions.

Parkinson's Disease Literature

Publication date: Dec 06, 2024 MicroRNAs (miRNAs) play a crucial role in regulating gene expression and influence many biological processes. Despite their importance, understanding of how genetic variation affects miRNA ... Read more

December 8, 2024December 8, 2024

Altered brain regional homogeneity, depressive symptoms, and cognitive impairments in medication-free female patients with current depressive episodes in bipolar disorder and major depressive disorder.

Major Depressive Disorder Literature

Publication date: Dec 06, 2024 Although symptoms of depressive episodes in patients with bipolar depressive episodes (BDE) and major depressive disorder (MDD) are similar, the treatment strategies for these disorders ... Read more

December 8, 2024December 8, 2024

Therapeutic targeting of the oxidative stress generated by pathological molecular pathways in the neurodegenerative diseases, ALS and Huntington’s.

Huntington's Disease Literature

Publication date: Dec 05, 2024 Neurodegenerative disorders are characterized by a progressive decline of specific neuronal populations in the brain and spinal cord, typically containing aggregates of one or more ... Read more