Publication date: Aug 05, 2019 The FOXC2 transcription factor promotes the progression of several cancer types, but has not been investigated in the context of melanoma cells. To study FOXC2’s ... Read more

Publication date: Oct 24, 2019 Glutaredoxin-1 (Glrx) is a small cytosolic enzyme that removes S-glutathionylation, glutathione adducts of protein cysteine residues, thus modulating redox signaling and gene transcription. Although Glrx ... Read more

Publication date: Oct 16, 2019 Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma ... Read more

Publication date: Sep 12, 2019 Growth hormone (GH) facilitates therapy resistance in the cancers of breast, colon, endometrium, and melanoma. The GH-stimulated pathways responsible for this resistance were identified as ... Read more

Publication date: Oct 09, 2019 Extracellular vesicles (EVs) are emerging as key players in intercellular communication. EVs can transfer biological macromolecules to recipient cells, modulating various physiological and pathological processes. ... Read more

Publication date: Oct 06, 2019 MicroRNAs are known to be critical regulators in tumor progression. miR-7-5p was reported to be involved in several cancers, including glioblastoma, cervical cancer and melanoma ... Read more

Publication date: Oct 01, 2019 P21-activated kinase-1 (PAK-1) is a serine/threonine kinase involved in multiple signaling pathways that mediate cellular functions such as cytoskeletal motility, cell proliferation, and survival. PAK-1 ... Read more

Publication date: Apr 23, 2019 To develop a model to evaluate the cost-utility of choroidal nevi monitoring recommendations with varying clinical risk factors. A Markov model was created to evaluate ... Read more

Publication date: Sep 12, 2019 To determine whether blockade of the chemokine receptor CXCR4 might alter the tumor microenvironment and inhibit tumor growth, we tested the efficacy of the CXCR4 ... Read more

Publication date: Sep 11, 2019 Uveal melanoma (UM) has a high mortality rate due to liver metastasis. The insulin-like growth factor-1 receptor (IGF-1R) is highly expressed in UM and has ... Read more