Search Results for: inflammation

July 15, 2019July 15, 2019

Toll-like receptors in the pathogenesis of neuroinflammation.

Publication date: Jul 15, 2019 Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later studies showed their involvement ... Read more

July 14, 2019July 14, 2019

Downregulation of lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson’s disease through the inhibition of the PI3K/Akt signaling pathway.

Parkinson's Disease Literature

Publication date: Jul 09, 2019 This study is conducted to investigate the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in the protection of dopaminergic neurons in Parkinson’s disease (PD) through ... Read more

July 13, 2019July 13, 2019

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer’s disease challenged mice.

Parkinson's Disease Literature

Publication date: Jul 08, 2019 Mild traumatic brain injury (mTBI) is a risk factor for neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). TBI-derived neuropathologies are promoted ... Read more

July 12, 2019July 12, 2019

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation Via Extracellular Vesicle-Mediated Delivery of miRNA.

Precision Medicine Literature

Publication date: Jul 10, 2019 Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring and stimulate regeneration of transparent stromal tissue after corneal wounding in mice. These ... Read more

July 8, 2019July 8, 2019

Immune checkpoint blocker-related sarcoid-like granulomatous inflammation: a rare adverse event detected in lymph node aspiration cytology of patients treated for advanced malignant melanoma.

Melanoma Literature

Publication date: Jul 04, 2019 Immune checkpoint inhibitors are a major breakthrough in the field of oncology. Targets for approved immune checkpoint inhibitors are cytotoxic T-lymphocytes-associated antigen 4 (CTLA-4) and ... Read more

July 4, 2019July 4, 2019

Association of MS Meningeal Inflammation Markers with Cortical Lesions

Multiple Sclerosis Media

Publication date: Jul 03, 2019 Neurology Today At the AAN Annual Meeting: Using 7-Tesla MRI, researchers found no strong relationship between biomarkers of meningeal inflammation and cortical lesions in patients ... Read more

July 4, 2019July 4, 2019

Neuronal damage and neuroinflammation markers in patients with autoimmune encephalitis and multiple sclerosis.

Multiple Sclerosis Literature

Publication date: Jul 02, 2019 Inflammatory diseases of the central nervous system (CNS) are a diagnostic challenge to clinicians. Autoimmune encephalitis (AE) is an important diagnostic consideration in patients with ... Read more

July 4, 2019July 4, 2019

T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response.

Multiple Sclerosis Literature

Publication date: Jul 03, 2019 Treatments for autoimmune diseases aim to dampen autoreactivity while preserving normal immune function. In CD4 T cells, the transcription factor Oct1/Pou2f1 is a dispensable transcription ... Read more

July 2, 2019July 2, 2019

Agent-based models of inflammation in translational systems biology: A decade later.

Precision Medicine Literature

Publication date: Jul 01, 2019 Agent-based modeling is a rule-based, discrete-event, and spatially explicit computational modeling method that employs computational objects that instantiate the rules and interactions among the individual ... Read more

June 30, 2019June 30, 2019

Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.

Multiple Sclerosis Literature

Publication date: Jun 27, 2019 Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms ... Read more