Search Results for: inflammation

May 4, 2022May 4, 2022

Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.

Melanoma Literature

Publication date: May 02, 2022 Brain metastasis is a significant cause of morbidity and mortality in multiple cancer types and represents an unmet clinical need. The mechanisms that mediate metastatic ... Read more

March 24, 2022March 24, 2022

Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers.

Melanoma Literature

Publication date: Mar 21, 2022 Posttraumatic stress disorder (PTSD) is associated with inflammation and various forms of chronic disease. The Absent in Melanoma 2 (AIM2) gene has been implicated in ... Read more

March 24, 2022March 24, 2022

Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers.

Melanoma Literature

May 24, 2022May 24, 2022

A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson's disease.

Parkinson's Disease Literature

Publication date: May 22, 2022 The α-synuclein released by neurons activates microglia, which then engulfs α-synuclein for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease ... Read more

May 22, 2022May 22, 2022

Serum Inflammatory Markers and Progression of Nonmotor Symptoms in Early Parkinson's Disease.

Parkinson's Disease Literature

Publication date: May 21, 2022 The influence of peripheral inflammation on nonmotor symptoms (NMSs) in Parkinson’s disease (PD) remains unclear. The aim of this study was to explore whether serum ... Read more

May 22, 2022May 22, 2022

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease.

Parkinson's Disease Literature

Publication date: May 21, 2022 The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is ... Read more

May 22, 2022May 22, 2022

Study explores if prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism

Parkinson's Disease News

Publication date: May 22, 2022 A new paper examines the possibility of similar syndromes following coronavirus disease 2019 (COVID-19). IntroductionViral infections sometimes affect non-target organs, including the brain, to cause ... Read more

May 21, 2022May 21, 2022

Exploring supportive care and information needs through a proposed eHealth application among melanoma patients undergoing systemic therapy: a qualitative study.

Melanoma Literature

Publication date: May 19, 2022 During and after systemic therapy, patients with high risk and advanced melanoma experience challenges regarding cancer-related symptoms, treatment-related adverse events, and an impact of these ... Read more

May 21, 2022May 21, 2022

circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease.

Parkinson's Disease Literature

Publication date: May 19, 2022 Circular RNA (circRNA) is a type of non-coding RNA that is widely expressed in mammals. It is highly conserved and abundantly expressed in the brain. ... Read more

May 21, 2022May 21, 2022

Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo.

Parkinson's Disease Literature

Publication date: May 19, 2022 Paraoxonase 1 (PON1) plays an anti-inflammatory role in the cardiovascular system. Levels of serum PON1 and polymorphisms in this gene were linked to Alzheimer’s disease ... Read more