Search Results for: melanoma

November 18, 2019November 18, 2019

Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity.

Melanoma Literature

Publication date: Nov 16, 2019 CircularRNAs (circRNAs) are non-coding RNAs which compete for microRNA (miRNA) binding, influencing the abundance and stability of other RNA species. Herein we have investigated the ... Read more

November 17, 2019November 17, 2019

Interleukin-18 Is a Prognostic Biomarker Correlated with CD8 T Cell and Natural Killer Cell Infiltration in Skin Cutaneous Melanoma.

Melanoma Literature

Publication date: Nov 15, 2019 Interleukin-18 (IL-18) is a cytokine that enhances innate and adaptive immune responses. Although there are conflicting reports about the roles of IL-18 in melanoma progression, ... Read more

November 17, 2019November 17, 2019

A T-helper 1/interferon- gene signature is prognostic in the adjuvant setting of resectable high-risk melanoma but not in non-small cell lung cancer.

Melanoma Literature

Publication date: Nov 15, 2019 Immune components of the tumor microenvironment (TME) have been associated with disease outcome. We prospectively evaluated the association of an immune-related gene signature (GS) with ... Read more

November 17, 2019November 17, 2019

Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma.

Melanoma Literature

Publication date: Nov 15, 2019 To report the 5-year overall survival (OS) landmark and the long-term safety profile of vemurafenib plus cobimetinib (BRAF plus MEK inhibition, respectively) in the BRIM7 ... Read more

November 17, 2019November 17, 2019

Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load.

Melanoma Literature

Publication date: Nov 16, 2019 Ultraviolet radiation-induced DNA mutations are a primary environmental driver of melanoma. The reason for this very high level of unrepaired DNA lesions leading to these ... Read more

November 16, 2019November 16, 2019

Circulating tumour DNA (ctDNA) as a biomarker in metachronous melanoma and colorectal cancer- a case report.

Melanoma Literature

Publication date: Nov 14, 2019 Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. The presence of ctDNA in ... Read more

November 16, 2019November 16, 2019

The density and spatial tissue distribution of CD8 and CD163 immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors.

Melanoma Literature

Publication date: Nov 15, 2019 Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to ... Read more

November 16, 2019November 16, 2019

Supramolecular Insights into Domino Effects of Ag@ZnO-induced Oxidative Stress in Melanoma Cancer Cells.

Melanoma Literature

Publication date: Nov 15, 2019 Recent studies suggest that cancer cell death accompanied by organelle dysfunction might be a promising approach for cancer therapy. The Golgi apparatus has a key ... Read more

November 16, 2019November 16, 2019

ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.

Melanoma Literature

Publication date: Nov 15, 2019 Dissecting the different steps of the processing and presentation of tumor-associated antigens is a key aspect of immunotherapies enabling to tackle the immune response evasion ... Read more

November 16, 2019November 16, 2019

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Melanoma Literature

Publication date: Nov 14, 2019 BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops. Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway inhibition is ... Read more