Publication date: Sep 13, 2019 Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily ... Read more

Publication date: Sep 13, 2019 Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here ... Read more

Publication date: Sep 13, 2019 Melanoma preventive interventions for children with familial risk are critically needed, because ultraviolet radiation (UVR) exposure and sunburn occurrence early in life are the primary ... Read more

Publication date: Sep 14, 2019 Guidelines for follow-up of melanoma patients are based on limited evidence. To guide skin surveillance, we developed a risk prediction model for subsequent primary melanoma ... Read more

Publication date: Sep 15, 2019 Uveal melanomas (UM) are genetically simple tumors carrying few copy number alterations (CNA) and a low mutation burden, except in rare MBD4-deficient, hypermutated cases. The ... Read more

Publication date: May 09, 2019 Programmed death-1 (PD-1) inhibitors are among the immunotherapies that have revolutionized our approach to treating several cancers. These novel agents act by blocking PD-1 receptor/PD-1 ... Read more

Publication date: Sep 11, 2019 Acquired resistance during BRAF inhibitor therapy remains a major challenge for melanoma treatment. Accordingly, we evaluated the phenotypical and molecular changes of isogeneic human V600E ... Read more

Publication date: Sep 11, 2019 According to clinical trials, BRAF kinase inhibitors in combination with MEK kinase inhibitors are among the most promising chemotherapy regimens for the treatment of advanced ... Read more

Publication date: Sep 11, 2019 Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary body. Electrochemotherapy (ECT) has ... Read more

Publication date: Sep 11, 2019 Thick melanomas, defined as ≥4 mm in thickness, represent ~5% of new melanoma diagnoses and have been associated with poor overall survival (OS). Ultrathick melanomas, those ... Read more