Search Results for: neurodegenerative diseases

September 19, 2019

What is strain in neurodegenerative diseases?

Publication date: Sep 17, 2019 Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are characterized by the aggregation of misfolded proteins, including Aβ, tau and α-synuclein. It is well ... Read more

September 12, 2019September 12, 2019

SUMOylation in Neurodegenerative Diseases.

Parkinson's Disease Literature

Publication date: Sep 10, 2019 Posttranslational modifications are ubiquitous regulators of cellular processes. The regulatory role of SUMOylation, the attachment of a small ubiquitin-related modifier to a target protein, has ... Read more

September 4, 2019September 4, 2019

Converging Pathologies in Neurodegenerative Diseases

Parkinson's Disease Media

Publication date: Sep 03, 2019 John Q. Trojanowski, MD, PhD, trained in pathology/neuropathology at Harvard Medical School, and the University of Pennsylvania. He joined the Penn faculty in 1981 where ... Read more

August 17, 2019August 17, 2019

Speech in prodromal and symptomatic Huntington’s disease as a model of measuring onset and progression in dominantly inherited neurodegenerative diseases.

Huntington's Disease Literature

Publication date: Aug 13, 2019 Subtle motor and cognitive changes can manifest prior to diagnosis in many progressive neurological disorders. Most people with Huntington’s disease (HD) develop dysarthria. Yet, how ... Read more

August 16, 2019August 16, 2019

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases.

Huntington's Disease Literature

Publication date: Aug 14, 2019 The most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease, frontotemporal lobar degeneration, and the motor neuron diseases, with AD affecting ... Read more

August 14, 2019August 14, 2019

Biomarkers in Neurodegenerative Diseases

Multiple Sclerosis News

Publication date: Aug 13, 2019 The general purpose of this observational study is to examine biomarkers associated with the pathology of neurodegenerative diseases to potentially develop novel therapeutic approaches. Concepts ... Read more

August 8, 2019August 8, 2019

Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

Parkinson's Disease News

Publication date: Aug 07, 2019 This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of ... Read more

August 1, 2019August 1, 2019

Emerging Perspectives on DNA double-strand breaks in Neurodegenerative Diseases.

Huntington's Disease Literature

Publication date: Jul 26, 2019 DNA double-strand breaks (DSBs) are common events that were recognized as one of the most toxic lesions in eukaryotic cells. DSBs are widely involved in ... Read more

August 1, 2019August 1, 2019

DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases.

Huntington's Disease Literature

Publication date: Jul 30, 2019 Recent genome-wide association studies of Huntington’s disease (HD) primarily highlighted genes involved in DNA damage repair mechanisms as modifiers of age at onset and disease ... Read more

July 11, 2019July 11, 2019

Olesoxime in Neurodegenerative Diseases: Scrutinising a Promising Drug Candidate.

Huntington's Disease Literature

Publication date: Jul 05, 2019 Over the last years, the experimental compound olesoxime, a mitochondria-targeting cholesterol derivative, has emerged as a promising drug candidate for neurodegenerative diseases. Numerous preclinical studies ... Read more