Search Results for: neurodegenerative diseases

July 11, 2019July 11, 2019

Olesoxime in Neurodegenerative Diseases: Scrutinising a Promising Drug Candidate.

Publication date: Jul 05, 2019 Over the last years, the experimental compound olesoxime, a mitochondria-targeting cholesterol derivative, has emerged as a promising drug candidate for neurodegenerative diseases. Numerous preclinical studies ... Read more

July 11, 2019July 11, 2019

Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling.

Multiple Sclerosis Literature

Publication date: Jul 06, 2019 Mitochondrial dysfunction is becoming one of the most emerging pathological process in the etiology of neurological disorders. Other common etiologies of the neurological disorders are ... Read more

July 11, 2019July 11, 2019

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases.

Multiple Sclerosis Literature

Publication date: Jul 08, 2019 Antisense oligonucleotides represent a novel therapeutic platform for the discovery of medicines that have the potential to treat most neurodegenerative diseases. Antisense drugs are currently ... Read more

June 28, 2019June 28, 2019

Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases.

Multiple Sclerosis Literature

Publication date: Jun 25, 2019 Within the last century, human lifestyle and dietary behaviors have changed dramatically. These changes, especially concerning hygiene, have led to a marked decrease in some ... Read more

June 18, 2019June 18, 2019

Accurate, rapid and reliable, fully automated MRI brainstem segmentation for application in multiple sclerosis and neurodegenerative diseases.

Multiple Sclerosis Literature

Publication date: Jun 17, 2019 Neurodegenerative disorders, such as Alzheimer’s disease (AD) and progressive forms of multiple sclerosis (MS), can affect the brainstem and are associated with atrophy that can ... Read more

June 15, 2019June 15, 2019

The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development.

Precision Medicine Literature

Publication date: Jun 14, 2019 Introduction: Neuroinflammation is a common pathophysiological mechanism in neurodegenerative diseases (ND). Cerebrospinal fluid (CSF) YKL-40 has recently been candidated as a neuroinflammatory biomarker of ND. ... Read more

June 1, 2019June 1, 2019

Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases.

Huntington's Disease Literature

Publication date: Jun 01, 2019 Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of ... Read more

May 29, 2019May 29, 2019

Anne Bertolotti (MRC LMB) 2: Benefits of Phosphatase Inhibition for Neurodegenerative Diseases

Huntington's Disease Media

Publication date: May 29, 2019 Protein Phosphatases Kinases and phosphatases perform a balancing act in cells by adding and removing phosphate groups from proteins. Dr. Bertolotti shows us that inhibiting ... Read more

May 12, 2019May 12, 2019

Microglia-mediated neuroinflammation in neurodegenerative diseases.

Huntington's Disease Literature

Publication date: May 08, 2019 Microglia, being the resident immune cells of the central nervous system, play an important role in maintaining tissue homeostasis and contributes towards brain development under ... Read more

May 12, 2019May 12, 2019

STIM Proteins and Glutamate Receptors in Neurons: Role in Neuronal Physiology and Neurodegenerative Diseases.

Huntington's Disease Literature

Publication date: May 09, 2019 Neuronal calcium (Ca) influx has long been ascribed mainly to voltage-gated Ca channels and glutamate receptor channels. Recent research has shown that it is also ... Read more