Search Results for: neuroinflammation

December 3, 2024December 3, 2024

Protective Effects of Antcin H Isolated from Antrodia cinnamomea Against Neuroinflammation in Huntington’s Disease via NLRP3 Inflammasome Inhibition.

Publication date: Dec 02, 2024 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene. When the ... Read more

December 3, 2024December 3, 2024

Lipopolysaccharide induces neuroinflammation in a valproic acid male model of autism.

Autism Literature

Publication date: Nov 30, 2024 Autism spectrum disorders (ASD) are characterized by social skill deficits and behavior impairments. Exposure to valproic acid (VPA) has been linked to ASD in humans ... Read more

December 3, 2024December 3, 2024

SARS-CoV-2 spike S1 protein induces microglial NLRP3-dependent neuroinflammation and cognitive impairment in mice.

Coronavirus Literature

Publication date: Jan 01, 2025 Cognitive impairment is often found at the acute stages and sequelae of coronavirus disease 2019 (COVID-19), and the underlying mechanisms remain unclear. The S1 protein ... Read more

November 26, 2024November 26, 2024

Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation.

Parkinson's Disease Literature

Publication date: Nov 23, 2024 Parkinson’s disease (PD) is characterized by the formation of α-synuclein (α-syn) aggregates, which lead to dopaminergic neuronal degeneration. The incidence of PD increases with age, ... Read more

November 26, 2024November 26, 2024

Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation.

Parkinson's Disease Literature

November 24, 2024November 24, 2024

Tim-3 Deficiency Ameliorates Motor Deficits and Neuroinflammation in MPP+/MPTP-Induced Parkinson’s Disease Models via the NF-κB/NLRP3 Pathway.

Parkinson's Disease Literature

Publication date: Nov 23, 2024 Parkinson’s disease (PD) is a common neurodegenerative disorder, and neuroinflammation plays a pivotal role in its pathogenesis. T-cell immunoglobulin and mucin-domain-containing molecule 3 (Tim-3) is ... Read more

November 19, 2024November 19, 2024

Salidroside Ameliorates Neuroinflammation in Autistic Rats by Inhibiting NLRP3/Caspase-1/GSDMD Signal Pathway.

Autism Literature

Publication date: Nov 16, 2024 Autism spectrum disorder (ASD) is a neurodevelopmental disorder that place a huge economic and emotional burden on society. Salidroside (Sal) has been reported to have ... Read more

November 19, 2024November 19, 2024

Mitochondrial DAMPs: Key Mediators in Neuroinflammation and Neurodegenerative Disease Pathogenesis.

Huntington's Disease Literature

Publication date: Nov 16, 2024 Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are increasingly linked to mitochondrial dysfunction and ... Read more

November 15, 2024November 15, 2024

Convergence of Neuroinflammation, Microbiota, and Parkinson’s Disease: Therapeutic Insights and Prospects.

Parkinson's Disease Literature

Publication date: Oct 29, 2024 Parkinson’s disease (PD) is a complex neurodegenerative disorder. Recent evidence reveals connections between neuroinflammatory processes and intestinal microbiota alterations in the progression of this pathology. ... Read more

November 15, 2024November 15, 2024

Microglia Sing the Prelude of Neuroinflammation-Associated Depression.

Major Depressive Disorder Literature

Publication date: Nov 13, 2024 Major depressive disorder (MDD) is a psychiatric condition characterized by sadness and anhedonia and is closely linked to chronic low-grade neuroinflammation, which is primarily induced ... Read more