Search Results for: neutropenia

April 28, 2025

Is neutropenia still the main risk factor for invasive aspergillosis? A contemporary university hospital retrospective cohort of invasive aspergillosis in neutropenic and non-neutropenic patients.

Publication date: Apr 25, 2025 In times of mold active prophylaxis, invasive aspergillosis (IA) epidemiology is evolving. Presentation in non-neutropenic may differ from neutropenic. We investigated the cases of IA ... Read more

May 13, 2025

Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study.

Coronavirus Literature

Publication date: May 11, 2025 The phase III SELECT-MONOTHERAPY trial (NCT02706951) demonstrated the safety and efficacy of upadacitinib (UPA) monotherapy through 84 weeks in patients with rheumatoid arthritis who responded ... Read more

May 12, 2025

Organ preservation after total neoadjuvant therapy for locally advanced rectal cancer (CAO/ARO/AIO-16): an open-label, multicentre, single-arm, phase 2 trial.

Coronavirus Literature

Publication date: Jun 01, 2025 Total neoadjuvant therapy has been shown to increase pathological complete response and disease-free survival in patients with locally advanced rectal cancer after total mesorectal excision ... Read more

May 7, 2025

Effective TIL therapy for patients with checkpoint-resistant melanoma without lymphodepleting regimens requires interferon-alpha.

Melanoma Literature

Publication date: May 06, 2025 Melanoma patients progressing despite immune checkpoint blockade (ICB) may benefit from adoptive transfer of tumor infiltrating lymphocytes (TIL). We investigated the impact of a pegylated ... Read more

May 7, 2025

BEAT Tuberculosis: a randomized controlled trial of a 6-month strategy for rifampicin-resistant tuberculosis

Tuberculosis News

Publication date: May 05, 2025 Background Safer, more effective treatment regimens for rifampicin-resistant tuberculosis are needed. We evaluated a novel six-month RR-TB treatment strategy. Methods We conducted a phase III, ... Read more

May 2, 2025

Safety, tolerability, and preliminary efficacy of nadunolimab, an anti-IL- 1 receptor accessory protein monoclonal antibody, in combination with pembrolizumab in patients with solid tumors.

Melanoma Literature

Publication date: May 01, 2025 Interleukin (IL)-1 signaling has an essential role in tumor progression and immunosuppression and is linked to acquired resistance to anti-PD-1/PD-L1 treatment. Nadunolimab is an IL1RAP ... Read more

May 1, 2025May 1, 2025

Statistical analysis plan for the “empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia” clinical trial.

Tuberculosis Literature

Publication date: Apr 30, 2025 The EMPIRICAL trial aims to assess safety and efficacy of an empirical treatment against cytomegalovirus (CMV) and tuberculosis (TB) compared to standard of care (SoC), ... Read more

April 30, 2025April 30, 2025

AU-007 Appears Safe and Effective for Solid Tumors, Phase 2 Findings Show

Melanoma News

Publication date: Apr 30, 2025 Two patients with melanoma who were refractory to antiCTLA-4 and PD-1 therapy had tumor reductions of 48% after 14 months and 100% at 10 months, ... Read more

April 30, 2025

Implications of Clozapine Monitoring During the COVID-19 Pandemic.

Coronavirus Literature

Publication date: Apr 30, 2025 Clozapine is the drug of choice for treatment-resistant schizophrenia. Routine monitoring of an absolute neutrophil count (ANC) is required to detect severe neutropenia, which is ... Read more

April 28, 2025

Comparative Insights into COVID-19 and Tuberculosis: Clinical Manifestations, Inflammatory Markers, and Outcomes in Pulmonary Versus Extrapulmonary Tuberculosis and SARS-CoV-2 Co-Infection.

Coronavirus Literature

Publication date: Apr 17, 2025 Background: Tuberculosis and COVID-19 co-infection poses significant clinical challenges, with pulmonary TB (PTB) and extrapulmonary TB (extraPTB) potentially influencing disease progression and outcomes differently. This ... Read more