Search Results for: pathological processes

Loss-of-huntingtin in medial and lateral ganglionic lineages differentially disrupts regional interneuron and projection neuron subtypes and promotes Huntington’s disease-associated behavioral, cellular and pathological hallmarks.

Loss-of-huntingtin in medial and lateral ganglionic lineages differentially disrupts regional interneuron and projection neuron subtypes and promotes Huntington’s disease-associated behavioral, cellular and pathological hallmarks.

Huntington's Disease Literature
Publication date: Jan 09, 2019 Emerging studies are providing compelling evidence that the pathogenesis of Huntington’s disease (HD), a neurodegenerative disorder with frequent midlife onset, encompasses developmental components. Moreover, our ... Read more
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weights compounds in counteracting its aggregation and nuclear translocation.

Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weights compounds in counteracting its aggregation and nuclear translocation.

Huntington's Disease Literature
Publication date: Sep 22, 2018 A number of independent studies have shown the contribution of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the pathogenesis of several neurodegenerative disorders. Indeed, GAPDH aggregates have been ... Read more