Search Results for: protein

December 12, 2024December 12, 2024

Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice.

Publication date: Dec 11, 2024 We previously reported that mutations outside the spike protein play a role in the attenuation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron ... Read more

December 12, 2024December 12, 2024

Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues.

Huntington's Disease Literature

Publication date: Dec 11, 2024 The incorporation of fluorinated amino acids into proteins provides new opportunities to study biomolecular structure-function relationships in an elegant manner. The available strategies to incorporate ... Read more

December 12, 2024December 12, 2024

An unusual activity of mycobacterial MutT1 Nudix hydrolase domain as a protein phosphatase regulates nucleoside diphosphate kinase function.

Tuberculosis Literature

Publication date: Dec 11, 2024 MutT proteins are Nudix hydrolases characterized by the presence of a Nudix box, GX5EX7REUXEEXGU, where U is a bulky hydrophobic residue and X is any ... Read more

December 12, 2024December 12, 2024

CancerHubs: a systematic data mining and elaboration approach for identifying novel cancer-related protein interaction hubs.

Dr. Richard A. Blevins Literature, Informatics Literature

Publication date: Nov 22, 2024 Conventional approaches to predict protein involvement in cancer often rely on defining either aberrant mutations at the single-gene level or correlating/anti-correlating transcript levels with patient ... Read more

December 12, 2024December 12, 2024

Machine learning reveals a functional network of genes and proteins in human cancer

Dr. Richard A. Blevins News, Informatics News

Publication date: Dec 12, 2024 By generating a comprehensive functional network, this approach provides a robust framework for cancer functional genomics research, offering valuable insights into mutations and cancer-associated proteins. ... Read more

December 11, 2024December 11, 2024

Biological and computational assessments of thiazole derivative-reinforced bile salt enriched nano carriers: a new gate in targeting SARS-CoV-2 spike protein.

Coronavirus Literature

Publication date: Dec 03, 2024 There is merit in investigating novel therapeutic molecules that hit vital targets during the viral infection cycle i. e. disrupting the interaction between SARS-CoV-2’s spike ... Read more

December 11, 2024December 11, 2024

SARITA: A Large Language Model for Generating the S1 Subunit of the SARS-CoV-2 Spike Protein

Coronavirus News

Publication date: Dec 09, 2024 The COVID-19 pandemic has profoundly impacted global health, economics, and daily life, with over 776 million cases and 7 million deaths from December 2019 to ... Read more

December 11, 2024December 11, 2024

SARITA: A Large Language Model for Generating the S1 Subunit of the SARS-CoV-2 Spike Protein

Coronavirus News

December 10, 2024December 10, 2024

Spontaneous formation of different forms of alpha-synuclein fibrils from a recombinant protein.

Parkinson's Disease Literature

Publication date: Dec 31, 2024 Alpha-synuclein is a protein, the conformational changes of which lead to the development of such socially significant diseases as Parkinson’s disease and amyotrophic lateral sclerosis. ... Read more

December 10, 2024December 10, 2024

Spontaneous formation of different forms of alpha-synuclein fibrils from a recombinant protein.

Parkinson's Disease Literature