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Discovery of potential RAF selective back pocket as a promising biological site for BRAF inhibitors targeting resistant melanoma opens the door for a new generation of kinase inhibitors: Design, synthesis, biological evaluation, and in silico molecular simulation.

Discovery of potential RAF selective back pocket as a promising biological site for BRAF inhibitors targeting resistant melanoma opens the door for a new generation of kinase inhibitors: Design, synthesis, biological evaluation, and in silico molecular simulation.

Melanoma Literature
Publication date: Jul 07, 2025 Despite the approved combination of BRAF and MEK inhibitors to treat drug-resistant melanoma, serious side effects associated with this combination have been reported, particularly referring ... Read more