Publication date: Jan 11, 2022 We aimed to assess the potential causal association between Parkinson’s disease (PD) and ischemic stroke (IS) with Mendelian randomization methods. Summary statistics data from two ... Read more

Publication date: Jan 10, 2022 An intronic expansion (AAGGG) in the RFC1 gene has recently been shown to cause recessively inherited cerebellar ataxia, neuropathy, and vestibular areflexia syndrome and, furthermore, ... Read more

Publication date: Jan 10, 2022 Disability in Parkinson’s disease (PD) is measured by standardised scales including the MDS-UPDRS, which are subject to high inter and intra-rater variability and fail to ... Read more

Publication date: Jan 11, 2022 Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain. The receptor exists in ... Read more

Publication date: Jan 06, 2022 Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathway ... Read more

Publication date: Jan 06, 2022 Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer’s disease (AD), ... Read more

Publication date: Jan 05, 2022 Central nervous system (CNS) disorders account for boundless socioeconomic burdens with devastating effects among the population, especially the elderly. The major symptoms of these disorders ... Read more

Publication date: Jan 06, 2022 People with central neurological disorders experience difficulties with dual-task walking due to disease-related impairments. The objective of this review was to provide a comprehensive examination ... Read more