Ingentium has developed a comprehensive knowledge management platform for the life sciences industry. We provide a range of products and services to enable data-driven discovery and development, including a powerful search engine, customizable disease-focused knowledge graphs, and integrated content management solutions. Our cutting-edge technology enables pharmaceutical and biotech companies to accelerate research and development, improve operational efficiency, and bring new drugs to market faster and more efficiently.

Our platform integrates vast amounts of public and proprietary content from diverse sources, including genomics, proteomics, clinical trials, and scientific literature. This wealth of information is presented in a semantically rich format, allowing researchers to easily discover meaningful connections and insights. Our flexible solutions are tailored to meet the specific needs of each organization, from pre-clinical research to clinical trials, and from drug discovery to post-market surveillance. At Ingentium, we are committed to helping our clients overcome the challenges of the complex and dynamic life sciences industry. Our solutions are designed to empower scientists, researchers, and analysts with the tools they need to transform data into knowledge, and knowledge into action. Contact us to learn more about how our platform can help your organization achieve its goals.

About Our Team and Experience

Ingentium is led by a team of experts with decades of experience in the fields of biomedical research, informatics, and artificial intelligence. The team is comprised of professionals with diverse backgrounds in pharmaceutical and medical research, computer science, and business, bringing a wealth of knowledge and skills to the company. With a passion for innovation and a commitment to excellence, the Ingentium team works tirelessly to develop and maintain cutting-edge technology solutions for the healthcare and life sciences industries. They strive to provide the best possible service to their clients and to help them achieve their goals through the power of advanced analytics and data-driven insights.

Keith Elliston, PhD – Executive Chairman

Dr. Elliston is a seasoned entrepreneur and a leader in the biomedical field. He is the co-founder and Executive Director of the i2b2 tranSMART Foundation, a non-profit organization focused on realizing the promise of precision medicine through open-source and open-data. He is also the founder and CEO of several biotechnology companies in the areas of biomedical computing, digital health and artificial intelligence. He brings over 15 years of experience in the pharmaceutical industry, where he built and ran bioinformatics and genomics efforts. Dr. Elliston has a track record of success in biotechnology as CSO, CEO, and Executive Chairman for more than a half-dozen companies. He has a strong sense of social responsibility, in 2011 he decided to give back, and spent 2 years building the systems biology efforts for Huntington’s Disease at CHDI, a non-profit virtual pharma focused on HD. He then co-Founded and served as CSO and CEO for the tranSMART Foundation, and Executive Director for its successor non-profit open-source effort, the i2b2 tranSMART Foundation, and is currently the CIO for the Open Source Pharma Foundation. Dr. Elliston is a proven leader with a track record of driving growth and innovation in the biomedical field.

Rudy Potenzone, PhD – Vice President and COO

Dr. Potenzone is a highly accomplished executive with a proven track record of delivering quality, profitable and customer-focused products. He excels in developing product roadmaps and corporate strategies, and has a wealth of experience in global life science, informatics, knowledge management, workflow systems and electronic laboratory notebooks. He is known for his ability to lead scientific and technology teams in the delivery of novel products and services. He has a deep understanding of organizational development and leadership, as well as executive team and board level communications. He is an expert in contract and vendor negotiations and management and is a respected speaker at pharma and IT industry forums. Dr. Potenzone has a unique ability to assess and implement acquisitions and is known for his excellent interpersonal skills with customers, employees and suppliers. With his strategic vision and leadership capabilities, Dr. Potenzone is poised to drive growth and success for any organization.

Richard Blevins, PhD – Vice President and CIO

Dr. Blevins is a seasoned executive with a wealth of experience in the pharmaceutical R&D industry. He is a leader and scientist with expertise in computational biology, informatics, chemistry, biochemistry, molecular biology, business development, and project/portfolio management. He has a strong leadership background, developed through departmental creation, staffing and administration in large pharma, small biotech, and academic environments. He is a visionary leader with a demonstrated ability to establish strong relationships with scientists and apply informatics techniques to biomedical research and drug discovery processes. Dr. Blevins is a strategic thinker with the ability to navigate complex challenges and drive innovation. He is a respected leader in the pharmaceutical R&D industry, and his skills and experience make him an asset to any organization.

About the Charisma Cognitive Intelligence Platform

Charisma is a cognitive intelligence platform that revolutionizes the way we search for and process vast amounts of unstructured data used and generated by an enterprise. Traditional databases are insufficient for handling the many types of media, sources, and languages in which information is now stored. Charisma addresses this problem by aggregating and semantically structuring data by meaning, then facilitating query and intelligent delivery of integrated results. It is capable of ingesting unstructured data from internal and public sources and conducts semantic normalization, metadata extraction, indexing, and normalization of the ingested material to allow the user to query vastly different types of data.

Charisma also has the ability to mine all sources of unstructured data to identify new knowledge such as disease biomarkers and pathways that were previously unconnected. The platform can be integrated with other tools, such as translational medicine platforms, to provide additional information feeds and automated curation for the data held inside the platform. Charisma allows scientists to quickly leverage large volumes of data that were previously unmanageable, enabling them to produce better science at a much faster rate. The result is that an organization can simultaneously do things it was previously unable to do and do it less expensively.

The Charisma Evidence Processing Pipeline

The Charisma Evidence Processing Pipeline is the workflow system behind the Charisma Cognitive Intelligence Platform. The pipeline comprises Crawlers, Evidence Data Preparation, Charisma Metadata, Charisma Categorization Engine, Charisma Clustering Engine, and Evidence Publication. The Charisma Categorization Engine automatically places evidence into the best-scored category against each machine learning model. The Charisma Clustering Engine generates a hierarchical list of named clusters that organize all knowledgebase evidence. Finally, the content is delivered through the Ingentium Magazines via RSS feeds, email reports, and social media platforms such as Twitter, Facebook, Slack and LinkedIn.

Charisma Machine Learning

Charisma Machine Learning is a suite of applications and algorithms used to process vast amounts of unstructured data for biomedical knowledgebases. The applications used include Mallet, Python NLTK, Python SciKit Learn, TensorFlow, and proprietary Ingentium applications. The algorithms used include sentence splitting, tokenization, lemmatization/stemming, POS tagging, shallow parsing, full parsing, support vector machines, and named entity recognition. These algorithms are used to map syntactic forms of words into their canonical base forms, to analyze the syntactic structure of sentences, and to categorize and recognize biomedical entities mentioned in text. By utilizing Charisma Machine Learning, Charisma is able to semantically structure and categorize vast amounts of unstructured data to provide valuable insights and knowledge for biomedical researchers and organizations.

The Ingentium Biomedical Knowledge Graph Scaffold

The Ingentium Biomedical Knowledge Graph Scaffold is a biomedical properties graph that contains the base nodes and edges required to represent the bulk of biomedical knowledge. It contains over 14 million interconnected nodes, including diseases, chemical compounds, biomolecules, and core concepts. The scaffold can be used to jumpstart internal knowledge graph efforts and can be augmented through the integration of knowledge sources like the Ingentium disease-focused knowledge bases. The scaffold is connected through more than 34 million edges, with various relationship codes and edge metadata for each type of relationship. The iKG semantic predication application is used to extract semantic predications from biomedical free text, which are processed and stored in the iKG.