Publication date: Mar 19, 2025 Antisense oligonucleotides (ASOs) specifically bind to target RNA sequences and regulate protein expression through various mechanisms. ASOs are a promising therapeutic approach for treating neurodegenerative ... Read more

Publication date: Mar 20, 2025 Huntington’s disease (HD) modifiers include mismatch-repair (MMR) genes, but their connections to neuronal pathogenesis remain unclear. Here, we genetically tested 9 HD genome-wide association study ... Read more

Publication date: Mar 21, 2025 Sodium and potassium-activated adenosine 5′-triphosphatase (Na+/K+-ATPase) is a pivotal plasma membrane enzyme involved in neuronal activity and cellular homeostasis. The dysregulation of these enzymes has ... Read more

Publication date: Mar 19, 2025 Identifying the effect of modifiable socio-environmental factors on Huntington’s disease (HD) symptoms onset and progression is of great value. The role of educational attainment in ... Read more

Publication date: Mar 18, 2025 Decades of research into human neurodegenerative diseases have revealed important similarities as well as dissimilarities between diseases. While investigations of specific mechanistic aspects of diseases ... Read more

Publication date: Mar 18, 2025 Antidopaminergic medications (ADM) are often used for symptom management of Huntington’s disease (HD). Evidence from past research suggests that ADMs are associated with worse clinical ... Read more

Publication date: Apr 01, 2025 GFM1 is a nuclear gene that plays a role in mitochondrial function. In recent decades, various homozygous and compound heterozygous mutations have been identified, leading ... Read more

Publication date: Mar 17, 2025 Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG expansion in the Huntingtin (HTT) gene. Given its simple genetic cause but complex ... Read more

Publication date: Dec 01, 2025 The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels. Mitochondria-associated endoplasmic reticulum membranes serve ... Read more

Publication date: Mar 21, 2025 Early stages of Huntington’s disease (HD) before the onset of motor and cognitive symptoms are characterized by imbalanced excitatory and inhibitory output from the cortex ... Read more