Publication date: Mar 22, 2025 Background. Gangliosides – glycosphingolipids that modulate cell signaling and neuronal functions – are decreased in Huntington disease (HD) models and the brain of patients. Restoring ... Read more

Publication date: Mar 18, 2025 Importance: Antidepressants are the most frequently prescribed medication in Huntington’s disease; this study examines the effect of antidepressants on disease progression. Objectives: Determine the effects ... Read more

Publication date: Mar 15, 2025 Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG-repeat expansion in exon-1 of the huntingtin gene. Currently, no disease-modifying therapies are available, ... Read more

Publication date: Mar 15, 2025 Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG-repeat expansion in exon-1 of the huntingtin gene. Currently, no disease-modifying therapies are available, ... Read more

Publication date: Mar 15, 2025 Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG-repeat expansion in exon-1 of the huntingtin gene. Currently, no disease-modifying therapies are available, ... Read more

Publication date: Mar 11, 2025 Despite many promising preclinical studies and decades of clinical trials, there remains a paucity of effective disease-modifying drugs in motor neuron disease. We aimed to ... Read more

Publication date: Mar 11, 2025 Despite many promising preclinical studies and decades of clinical trials, there remains a paucity of effective disease-modifying drugs in motor neuron disease. We aimed to ... Read more

Publication date: Mar 12, 2025 Huntington’s disease (HD) is a debilitating hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is characterized by deposition of ... Read more

Publication date: Mar 12, 2025 Huntington’s disease (HD) is a debilitating hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is characterized by deposition of ... Read more

Publication date: Mar 06, 2025 The goal of this clinical trial is to test if the drug SKY-0515, an oral medication, can lower harmful proteins linked to Huntington’s Disease (HD) ... Read more