Melanoma Literature

May 28, 2020May 28, 2020

[The role of new molecular tests in the diagnosis of melanoma in a setting of congenital nævus in an infant].

Melanoma Literature

Publication date: May 22, 2020 Congenital and infantile melanomas are extremely rare. We report a case of a child presenting at birth with a giant congenital nevus complicated by melanoma ... Read more

May 28, 2020May 28, 2020

Dermoscopy comparative approach for early diagnosis in familial melanoma: influence of MC1R genotype.

Melanoma Literature

Publication date: May 26, 2020 MC1R polymorphisms interact with CDKN2A mutations modulating melanoma risk and contribute to a less suspicious clinical and dermoscopic appearance of melanomas. Different strategies, including dermoscopic ... Read more

May 28, 2020May 28, 2020

Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents.

Melanoma Literature

Publication date: May 26, 2020 Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through ... Read more

May 28, 2020May 28, 2020

Elevating the art of medicine: A caregiver’s reflection.

Melanoma Literature

Publication date: May 26, 2020 The following narrative chronicles the unlikely events of the author, an editorial director of an oncology publication, whose experience with cancer was purely academic in ... Read more

May 28, 2020May 28, 2020

Impact of modern systemic therapies and clinical markers on treatment outcome for metastatic melanoma in a real-world setting.

Melanoma Literature

Publication date: May 26, 2020 The survival in metastatic melanoma has dramatically improved after the introduction of immune checkpoint- (ICIs) and MAPKinase inhibitors (MAPKis). Our aim was to describe therapy ... Read more

May 28, 2020May 28, 2020

Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ.

Melanoma Literature

Publication date: May 26, 2020 The G protein coupled receptor, Endothelin receptor B (EDNRB), is an important regulator of melanocyte survival and proliferation. It acts by stimulating downstream heterotrimeric G ... Read more

May 28, 2020May 28, 2020

Detectable size of melanoma metastases to brain on PET/CT.

Melanoma Literature

Publication date: May 25, 2020 We aimed to determine at what size melanoma metastases become detectable by PET/CT. We reviewed a total of 293 whole-body PET/CT studies performed on 212 ... Read more

May 28, 2020May 28, 2020

Norepinephrine release may play a critical role in the Warburg effect: an integrative model of tumorigenesis.

Melanoma Literature

Publication date: May 26, 2020 Many cancer cells share the property of carrying out markedly elevated rates of glycolysis to generate energy even in the presence of sufficient oxygen, and ... Read more

May 28, 2020May 28, 2020

Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism.

Melanoma Literature

Publication date: May 25, 2020 We have recently developed an enzyme-directed immunostimulant (EDI) prodrug motif, which is metabolized to active immunostimulant by cancer cells and, following drug efflux, activates nearby ... Read more

May 28, 2020May 28, 2020

Common germline variants of the human APOE gene modulate melanoma progression and survival.

Melanoma Literature

Publication date: May 25, 2020 Common germline variants of the APOE gene are major risk modifiers of neurodegenerative and atherosclerotic diseases, but their effect on cancer outcome is poorly defined. ... Read more