Publication date: Aug 01, 2020 Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint inhibitors (ICI). Herein, we ... Read more

Publication date: Aug 01, 2020 The optimal sequence of stereotactic radiotherapy (SRT) and immune checkpoint inhibition (ICI) and assessment of response in patients with brain metastases from melanoma remain challenging. ... Read more

Publication date: Aug 03, 2020 Small molecule inhibitors targeting mutant epidermal growth factor receptor (EGFR) are standard of care in non-small cell lung cancer (NSCLC), but acquired resistance invariably develops ... Read more

Publication date: Aug 03, 2020 Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments ... Read more

Publication date: Aug 03, 2020 Gold (AuNP) and silver (AgNP) nanoparticles have been incorporated into many therapeutic and diagnostic applications. However, previous studies revealed toxic properties as well as hormesis ... Read more

Publication date: Aug 03, 2020 Hematopoietic cell transplantation (HCT) is a curative option for a growing number of patients with hematologic diseases and malignancies. However, HCT-related factors, such as total ... Read more

Publication date: Aug 03, 2020 As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy. Taking into account the many recent advances in DC biology, ... Read more

Publication date: Aug 03, 2020 Despite unprecedented advances in the treatment of cancer through the use of immune checkpoint blockade, responses are not universal and alternative strategies are needed to ... Read more

Publication date: Aug 03, 2020 We sought to identify patient subgroups with distinct postprogression overall survival (ppOS) outcomes and investigate the impact of original treatment assignment and initial postprogression treatment ... Read more

Publication date: Aug 03, 2020 Melanoma is the most deadly skin cancer and its incidence is growing. EZH2, a member of the Polycomb Group (PcGs) proteins family, plays an important ... Read more