Publication date: Jul 01, 2021 Uveal melanoma is a rare intraocular tumour, for which there is currently no national evidence-based guideline in Germany. The aim of this project was to ... Read more

Publication date: Jul 01, 2021 Over the last ten years, much has been learnt about the genetic characteristics and genetic evolution of uveal melanoma. It has been shown that uveal ... Read more

Publication date: Aug 09, 2021 Therapy resistance arises from heterogeneous drug-tolerant persister cells or minimal residual disease (MRD) through genetic and nongenetic mechanisms. A key question is whether specific molecular ... Read more

Publication date: Aug 09, 2021 In patients with melanoma and in in vivo models, gut colonization by Bacteroides intestinalis is associated with increased immune-related adverse events, such as colitis, resulting ... Read more

Publication date: Aug 09, 2021 Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor ... Read more

Publication date: Aug 09, 2021 The validity of circulating tumour DNA (ctDNA) as an indicator of disease progression compared to medical imaging in patients with metastatic melanoma requires detailed evaluation. ... Read more

Publication date: Aug 10, 2021 Uveal Melanoma (UM) is a rare cancer deriving from melanocytes within the uvea. It has a high rate of metastasis, especially to the liver, and ... Read more

Publication date: Aug 10, 2021 Small interfering RNA (siRNA)-based drugs have shown tremendous potential to date in cancer gene therapy. Despite the considerable efforts in siRNA design and manufacturing, unsatisfactory ... Read more

Publication date: Aug 10, 2021 This report characterizes and quantifies endogenous hydrogen sulfide (HS) and small oxoacids of sulfur (SOS = HOSH, HOSOH) in a panel of cell lines including ... Read more

Publication date: Aug 10, 2021 Mitosis is a prognostic factor for cutaneous melanoma (CM), but accurate mitosis detection in CM tissues is difficult. Therefore, the 8th Edition of the American ... Read more