Publication date: Sep 22, 2020 This webinar, Part 3 of the -Advances in RNA-based Biomarker Development for Precision Oncology” webinar series sponsored by GeneCentric Therapeutics, will discuss novel and emerging ... Read more

Publication date: Sep 24, 2020 More than half of high-risk patients with resected, stage III BRAF V600-mutated melanoma who were treated with dabrafenib (Tafinlar, Novartis) and trametinib (Mekinist, Novartis) were ... Read more

Publication date: Sep 22, 2020 This phase I/II trial investigates the best dose and side effects of tazemetostat and how well it works in combination with dabrafenib and trametinib in ... Read more

Publication date: Sep 22, 2020 A collaborative study led by Monash University’s Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that ... Read more

Publication date: Sep 18, 2020 Malignant melanoma is the deadliest form of skin cancer and, in recent years, is rapidly growing in terms of the incidence worldwide rate. The most ... Read more

Publication date: Sep 18, 2020 Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target ... Read more

Publication date: Sep 18, 2020 It is commonly believed that B cells play no role in cancer immune surveillance. However, this conclusion is based on studies using only a single ... Read more

Publication date: Sep 18, 2020 In the melanoma cohort, of the five evaluable melanoma patients, one had a confirmed partial response (PR) and two had stable disease. Since the .. ... Read more

Publication date: Sep 18, 2020 Patients in arm A (n = 69) .. . Concepts Keywords BRAF MEK inhibitor Immunotherapy Immunotherapy Melanoma Metastasis Mutation BRAF Binimetinib Benzamides Melanoma Encorafenib Clinical ... Read more

Publication date: Sep 19, 2020 Novartis has shared data from the failed phase 3 melanoma trial of its anti-PD-1 checkpoint inhibitor spartalizumab. The readout showed adding .. . Concepts Keywords ... Read more