Publication date: Apr 20, 2021 In Parkinson disease (PD), pathological processes and neurodegeneration begin long before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal phase, risk ... Read more

Publication date: Apr 20, 2021 During the prodromal period of Parkinson’s disease and other α-synucleinopathy-related parkinsonisms, neurodegeneration is thought to progressively affect deep brain nuclei, such as the locus coeruleus, ... Read more

Publication date: Apr 20, 2021 Parkinson’s disease is characterized by both hypokinetic and hyperkinetic symptoms. While increased subthalamic burst discharges have a direct causal relationship with the hypokinetic manifestations (e. ... Read more

Publication date: Apr 21, 2021 BACKGROUND A lack of physical exercise, a critical aspect of a healthy lifestyle, contributes to several cerebral diseases, such as cognitive impairment, Parkinson disease (PD), ... Read more

Publication date: Apr 21, 2021 Gastrointestinal symptoms and gut dysbiosis may occur before the onset of motor symptoms in Parkinson’s disease (PD). Prediagnostic and prodromal features, such as constipation and ... Read more

Publication date: Apr 21, 2021 To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) of patients with pure autonomic failure (PAF) as ... Read more

Publication date: Apr 21, 2021 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases after Alzheimer’s disease (AD), afflicting adults above the age of sixty irrespective of gender, ... Read more

Publication date: Apr 21, 2021 Glutamate excitotoxicity is caused by dysfunctional glutamate transporters and plays an important role in the pathogenesis of Parkinson’s disease (PD); however, the mechanisms that underlie ... Read more

Publication date: Apr 19, 2021 Ferroptosis plays a critical regulatory role for a new kind of cell death initiating and developing an array of disorders like neurological diseases, acute injury ... Read more

Publication date: Apr 19, 2021 Few studies have explored the shared effects of Parkinson’s disease (PD) within patient/caregiver dyads. To fill this gap, we compared stress-health outcomes of patients with ... Read more