Publication date: Dec 04, 2019 The complexity of Parkinson’s disease (PD) pathogenesis is attributed to multiple pathways involved in the neurodegeneration process. Among these pathways arise the phosphoinositide 3-kinase (PI3K)/protein ... Read more

Publication date: Dec 06, 2019 In vitro conversion assays, including real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA) techniques, were first developed to study the conversion process of ... Read more

Publication date: Dec 06, 2019 Rotenone (ROT)-induced neurotoxicity has been used for decades as an animal model of Parkinson’s disease (PD) in humans. This model exhibits pathophysiological features similar to ... Read more

Publication date: Dec 06, 2019 Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer’s disease, Parkinson’s disease (PD) and sepsis. Despite microglial cells being the central ... Read more

Publication date: Dec 06, 2019 Pramipexole (PPX) is a common drug for the treatment of Parkinson’s disease. However, the mechanism allows PPX in the progression of Parkinson’s disease remains largely ... Read more

Publication date: Dec 03, 2019 Misfolding of the neuronal protein ?-synuclein into amyloid fibrils is a pathological hallmark of Parkinson’s disease, a neurodegenerative disorder that has no cure. Inhibition of ... Read more

Publication date: Dec 04, 2019 To investigate the effect of high-intensity interval training (HIIT) versus moderate-intensity continuous exercise training (MICE) on hemodynamic and functional variables in individuals with Parkinson’s disease. ... Read more

Publication date: Dec 03, 2019 Parkinson’s disease (PD) is a neurodegenerative disease with a 200 year-long research history. Our understanding about its clinical phenotype and pathogenesis remains limited, although dopaminergic ... Read more

Publication date: Dec 05, 2019 The non-motor features of Parkinson’s disease (PD) are increasingly being recognised. This review deals with the spectrum of sleep disorders associated with PD, which have ... Read more

Publication date: Dec 05, 2019 Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into ... Read more