Publication date: Oct 09, 2019 The G2019S substitution in the kinase domain of LRRK2 (LRRK2) is the most prevalent mutation associated with Parkinson’s disease (PD). Neurotoxic effects of LRRK2 are ... Read more

Publication date: Oct 11, 2019 Literature derived knowledge assemblies have been used as an effective way of representing biological phenomenon and understanding disease etiology in systems biology. These include canonical ... Read more

Publication date: Oct 11, 2019 Gait analysis of transgenic mice and rats modeling human diseases often suffers from the condition that those models exhibit genotype-driven differences in body size, weight, ... Read more

Publication date: Oct 01, 2019 Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting about 5 million people worldwide with no disease-modifying therapies. We sought blood-based biomarkers in order to ... Read more

Publication date: Oct 08, 2019 It is well known that most patients with Parkinson’s disease (PD) have different degree of movement disorders, such as shuffling, festination and akinetic episodes, which ... Read more

Publication date: Oct 08, 2019 Nanoparticle tracking analysis (NTA) is an important technique for measuring hydrodynamic size of globular biological particles including liposomes and viruses. Less attention has been paid ... Read more

Publication date: Oct 08, 2019 The complexity of Alzheimer’s disease (AD) complicates the search for effective treatments. While the key roles of pathologically modified proteins has occupied a central role ... Read more

Publication date: Oct 09, 2019 Proper folding is crucial for proteins to achieve functional activity in the cell. However, it often occurs that proteins are improperly folded (misfolded) and form ... Read more

Publication date: Oct 11, 2019 Morales-Brice~no, H., Mahant, N., Ha, A.D., Chang, F.C.F., Kim, S.D., Griffith, J., Tsui, D., Galea, D., and Fung, V.S.C. Long-term safety and efficacy of 24-hour ... Read more

Publication date: Oct 11, 2019 The past decade has seen a surge in the number of disease/trait-associated variants, largely because of the union of studies to share genetic data and ... Read more