Publication date: May 14, 2019 Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During the course ... Read more

Publication date: May 13, 2019 Folate metabolism plays quite a critical role in Parkinson’s disease (PD). Previous published research works have studied the link existing between the folate metabolism genetic ... Read more

Publication date: Aug 16, 2019 : Accumulative evidence indicated that the pathologically accumulated metal ions (iron species and Mn) and abnormally up-regulated monoamine oxidase B (MAOB) activity induced oxidation of ... Read more

Publication date: Aug 17, 2019 Recently, 5 previously Parkinson’s disease (PD)-related loci: ACMSD/TMEM163, STK39, MIR4697, SREBF1/RAI1PD and MAPT, have been associated to PD in a Southern Spanish population. However, due ... Read more

Publication date: Aug 17, 2019 In this paper, we report a clinically proven case of Parkinson’s disease (PD) with early onset in a patient who is a heterozygous mutation carrier ... Read more

Publication date: Aug 17, 2019 Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, affect millions of people and pose major personal and socioeconomic burdens. The causes of neurodegeneration are mostly unknown, ... Read more

Publication date: Aug 19, 2019 Complications from Parkinson’s disease may develop over the disease course, sometimes unexpectedly, and require prompt or even urgent medical intervention. The most common are associated ... Read more

Publication date: Aug 19, 2019 Protein degradation by the ubiquitin-proteasome system is critical for neuronal function. Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to synapses, but how proteasomes are ... Read more

Publication date: Aug 19, 2019 Perfluorooctane sulfonate (PFOS) has been widely utilized in numerous industries. Due to long environmental and biological half-lives, PFOS is a major public health concern. While ... Read more

Publication date: Aug 20, 2019 Mutations in the LRRK2 kinase are the most common cause of familial Parkinson’s disease, and variants increase risk for the sporadic form of the disease. ... Read more