Publication date: May 22, 2022 The α-synuclein released by neurons activates microglia, which then engulfs α-synuclein for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease ... Read more

Publication date: May 22, 2022 The aim of the current study is to understand why some individuals avoid developing Parkinson’s disease (PD) in spite of being at relatively high genetic ... Read more

Publication date: May 22, 2022 Long-term levodopa therapy for Parkinson’s disease (PD) can cause levodopa induced dyskinesia (LID). Genetic predisposition has a significant role to play in inter-individual heterogeneity in ... Read more

Publication date: May 23, 2022 Several genetic variants are associated with an increased risk for developing Parkinson’s Disease (PD) and limited genotype/phenotype correlation. Specifically, mutations in GBA1, the gene coding ... Read more

Publication date: May 23, 2022 Freezing of gait (FOG) is a disabling gait disorder in patients with Parkinson’s disease (PD), characterized by recurrent episodes of halting steps. Dopaminergic drugs are ... Read more

Publication date: May 23, 2022 Introduction: Parkinson’s disease (PD) is characterized by high-rates of depression with limited evidence-based treatment options to improve mood. Objective: To expand therapeutic options, we evaluated ... Read more

Publication date: May 23, 2022 Patients with Parkinson’s disease (PD) show impaired performance in taste recognition tests, which suggests a possible dopaminergic influence on gustatory functioning. To experimentally test this ... Read more

Publication date: May 23, 2022 The ability to differentiate similar choreic involuntary movements could lay the groundwork for the development of a minimally-invasive screening tool for their etiology and provide ... Read more

Publication date: May 23, 2022 Dopamine cells in the ventral tegmental area (VTA) are critical for a variety of motivated behaviors. These cells receive synaptic inputs from over 100 anatomically-defined ... Read more

Publication date: May 23, 2022 Dopamine replacement therapy with levodopa is the gold standard treatment of Parkinson’s disease (PD); however long-term levodopa use is associated with abnormal involuntary movements known ... Read more