Publication date: Mar 21, 2025 Neurodegenerative disorders include Parkinson’s disease, spinal cord injury, multiple sclerosis and Alzheimer’s disease, cause gradual neuronal loss, protein misfolding, and accumulation, resulting in severe cognitive ... Read more

Publication date: Mar 21, 2025 Neurodegenerative diseases, such as Alzheimer’s Disease (AD), Multiple Sclerosis (MS), Parkinson’s Disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are increasingly prevalent as global populations age. ... Read more

Publication date: Mar 21, 2025 Parkinson’s disease (PD) is a progressive, neurodegenerative disorder for which there is currently no cure. Gene therapy has emerged as a novel approach offering renewed ... Read more

Publication date: Mar 21, 2025 The neutrophil-to-lymphocyte ratio (NLR) is widely regarded as a proxy for system inflammation. The previous study indicated that the NLR might be higher in Parkinson’s ... Read more

Publication date: Mar 22, 2025 The relationship between LRRK2 mutations and susceptibility to synuclein pathology in Parkinson’s disease (PD) is still unclear. We here investigate whether the mice carrying the ... Read more

Publication date: Mar 22, 2025 Traditional advanced therapies in Parkinson’s disease (PD) with motor fluctuations and dyskinesias like continuous apomorphine infusion (CSAI), levodopa-carbidopa intestinal gel (LCIG), levodopa-carbidopa entacapone intestinal gel ... Read more

Publication date: Mar 22, 2025 As Parkinson’s disease (PD) progresses, patients experience motor fluctuations, which may manifest as motor and/or non-motor wearing off symptoms, delayed “ON” time, and/or levodopa-related dyskinesia. ... Read more

Publication date: Mar 22, 2025 The recently proposed body-first and brain-first subtypes are classified based on the initial localization of α-synuclein inclusions. This study investigated plasma biomarkers and cerebral glucose ... Read more

Publication date: Mar 22, 2025 The prevalence of respiratory dysfunction in PD is unknown and a better understanding of determinants contributing to respiratory dysfunction is important to facilitate early recognition ... Read more

Publication date: Mar 22, 2025 Neurodegenerative diseases are multi-faceted disorders influenced by and affecting more than just the brain and nervous system. Here, we provide a review of the potential ... Read more