Publication date: Jan 17, 2020 There is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes. To develop a scale to monitor clinical ... Read more

Publication date: Jan 13, 2020 In search of the compounds that interfere with amyloid transformation of alpha-synuclein, 9 natural and synthetic cinnamic acid derivatives were studied. They are structurally similar ... Read more

Publication date: Jan 17, 2020 Apathy is a debilitating neurological syndrome known to be associated with executive dysfunction, particularly affecting abstract reasoning. However, the underlying cognitive mechanism remains unclear. Recently, ... Read more

Publication date: Jan 17, 2020 A novel series of C(3)-substituted-piperdinylindoles were developed as nociceptin opioid receptor (NOP) partial agonists to explore a pharmacological hypothesis that NOP partial agonists would afford ... Read more

Publication date: Jan 16, 2020 Br”ussow, H. Parkinson disease, levodopa and the gut microbiota-when microbiology meets pharmacology. 23673. 2020 Environ Microbiol. Concepts Keywords Gut Microbiota Parkinson disease Levodopa Branches of ... Read more

Publication date: Jan 16, 2020 Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been proposed as a treatment strategy for gait disorder in patients with Parkinson’s disease (PD). ... Read more

Publication date: Jan 16, 2020 Nanoparticles (NPs) are unique may be organic, or inorganic, play a vital role in the development of drug delivery targeting the brain and central nervous ... Read more

Publication date: Jan 17, 2020 Pathogenic variants in the small GTPase Ras Analogue in Brain 39b (RAB39B) have been linked to the development of early-onset parkinsonism. The study was aimed ... Read more

Publication date: Jan 16, 2020 Wearable motion sensors are gaining popularity for monitoring free-living physical activity among people with Parkinson disease (PD), but more evidence supporting the accuracy and precision ... Read more

Publication date: Jan 14, 2020 Cognitive dysfunction is one of the most prevalent non-motor aspects of Parkinson’s disease (PD). The present review focuses on published studies investigating the effect of ... Read more