Publication date: Oct 09, 2019 Gliomas are tumors that originate from the glial tissue, thus involving the central nervous system with varying degrees of malignancy. The most aggressive and frequent ... Read more

Publication date: Oct 11, 2019 Given the global burden of heart failure, strategies to understand the underlying cause or to provide prognostic information are critical to reducing the morbidity and ... Read more

Publication date: Oct 11, 2019 Whole Genome Sequencing (WGS) provides an in depth description of genome variation. In the era of large-scale population genome projects, the assembly of ethnic-specific genomes ... Read more

Publication date: Oct 11, 2019 Cells grown in three dimensions (3D) within natural extracellular matrices or synthetic scaffolds more closely recapitulate the phenotype of those cells within tissues in regard ... Read more

Publication date: Oct 09, 2019 Over the time period from 2006 to 2017, consecutive patients operated on at the University Medical Center Rostock participated in the comprehensive biobanking and tumor-modelling ... Read more

Publication date: Oct 11, 2019 Intraoperative hypotension is associated with increased morbidity and mortality. Current treatment is mostly reactive. The Hypotension Prediction Index (HPI) algorithm is able to predict hypotension ... Read more

Publication date: Oct 11, 2019 The carboxylesterase drug hydrolysis pathway has been used extensively to improve the oral availability of drugs under the assumption that the high capacity and low ... Read more

Publication date: Oct 10, 2019 The activity of drug-metabolizing enzymes (DME) shows high inter- and intra-individual variability. Genetic polymorphisms, exposure to drugs, and environmental toxins are known to significantly alter ... Read more

Publication date: Oct 10, 2019 KEY MESSAGES eHealth should support the transition towards personalized medicine, self-management and shared decisions in primary care. Several conditions need to be met to ensure ... Read more

Publication date: Oct 10, 2019 An ongoing challenge in understanding and treating personality disorders (PDs) is a significant heterogeneity in disorder expression, stemming from variability in underlying dynamic processes. These ... Read more