Huntington’s disease, also known as Huntington’s chorea, is a hereditary neurodegenerative disorder that affects both the brain and the body. It is named after Dr. George Huntington, who first described the condition in the late 19th century.
Huntington’s disease is caused by a genetic mutation in the huntingtin gene (HTT), which leads to the production of abnormal huntingtin protein. The mutation involves an abnormal repetition of the CAG trinucleotide within the gene, causing an expansion of the repeating sequence. The more repeats a person has, the earlier and more severe the onset of the disease tends to be.
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