The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.
Publication date: Oct 09, 2019 The G2019S substitution in the kinase domain of LRRK2 (LRRK2) ...
Parkinson’s Disease
This magazine is directed toward patients with Parkinson’s Disease, their families, care givers, physicians and researchers. The content is gathered, validated, categorized, and supplied using a novel big data cyberinfrastructure technology that continually learns about Parkinson’s Disease.
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Quantifying mechanisms in neurodegenerative diseases (NDDs) using candidate mechanism perturbation amplitude (CMPA) algorithm.
Publication date: Oct 11, 2019 Literature derived knowledge assemblies have been used as an effective ... -
Silhouette-length-scaled gait parameters for motor functional analysis in mice and rats.
Publication date: Oct 11, 2019 Gait analysis of transgenic mice and rats modeling human diseases ... -
Understanding protein aggregation over time can help decipher early stages of Parkinson’s
Publication date: Oct 11, 2019 One of the biggest difficulties in treating Parkinson’s disease, a ... -
Deciphering the early stages of Parkinson’s disease is a matter of time
Publication date: Oct 12, 2019 For the first time, scientists observed how variants of the ... -
Ask the MD: Medical Marijuana and Parkinson’s Disease
Publication date: Oct 11, 2019 Does medical marijuana help Parkinson’s symptoms? Rachel Dolhun, MD, movement ... -
Characterization of Parkinson’s disease using blood-based biomarkers: A multicohort proteomic analysis.
Publication date: Oct 01, 2019 Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting about ... -
A dual-modal attention-enhanced deep learning network for quantification of Parkinson’s disease characteristics.
Publication date: Oct 08, 2019 It is well known that most patients with Parkinson’s disease ... -
Evaluation of nanoparticle tracking analysis for the detection of rod-shaped particles and protein aggregates.
Publication date: Oct 08, 2019 Nanoparticle tracking analysis (NTA) is an important technique for measuring ... -
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective.
Publication date: Oct 08, 2019 The complexity of Alzheimer’s disease (AD) complicates the search for ... -
Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases.
Publication date: Oct 09, 2019 Proper folding is crucial for proteins to achieve functional activity ... -
Long-term safety and efficacy of 24-hour levodopa-carbidopa intestinal gel in Parkinson’s disease.
Publication date: Oct 11, 2019 Morales-Brice~no, H., Mahant, N., Ha, A.D., Chang, F.C.F., Kim, S.D., ... -
Informing disease modelling with brain-relevant functional genomic annotations.
Publication date: Oct 11, 2019 The past decade has seen a surge in the number ... -
Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson’s disease.
Publication date: Oct 11, 2019 Reduced levels of dopamine in Parkinson’s disease contribute to changes ... -
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson’s disease with impulsive compulsive behaviours.
Publication date: Oct 11, 2019 Impulsive compulsive behaviours in Parkinson’s disease have been linked to ... -
SubMito-XGBoost: predicting protein submitochondrial localization by fusing multiple feature information and eXtreme gradient boosting.
Publication date: Oct 11, 2019 Mitochondria are an essential organelle in most eukaryotes. They not ... -
Sex differences in Parkinson’s disease: A transcranial magnetic stimulation study.
Publication date: Oct 11, 2019 Demographic and clinical studies imply that female sex may be ... -
Peripheral Immune Biomarkers and Neurodegenerative Diseases: A Prospective Cohort Study with 20 Years of Follow-up.
Publication date: Oct 11, 2019 To assess the associations of several blood immune biomarkers with ... -
Clinical outcomes of pallidal deep brain stimulation for dystonia implanted using intraoperative MRI.
Publication date: Oct 11, 2019 Lead placement for deep brain stimulation (DBS) using intraoperative MRI ... -
Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson’s Disease
Publication date: Oct 10, 2019 Parkinson’s disease (PD) is a difficult to treat condition that ... -
Objective Quality of Life Detection Validation
Publication date: Oct 10, 2019 The purpose of this research study is to: – Collect ...